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- A multi-pronged approach to targeting myeloproliferative neoplasms
- A new paradigm of machine learning-based structural variant detection
- A whole lot of junk or a treasure trove of discovery?
- Advanced imaging interrogation of pathogen induced NETosis
- Analysing the metabolic interactions in brain cancer
- Atopic dermatitis causes and treatments
- Boosting the efficacy of immunotherapy in lung cancer
- Building a cell history recorder using synthetic biology for longitudinal patient monitoring
- Characterisation of malaria parasite proteins exported into infected liver cells
- Deciphering the heterogeneity of the tissue microenvironment by multiplexed 3D imaging
- Defining the mechanisms of thymic involution and regeneration
- Delineating the molecular and cellular origins of liver cancer to identify therapeutic targets
- Developing computational methods for spatial transcriptomics data
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- Discovering epigenetic silencing mechanisms in female stem cells
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- Dissecting mechanisms of cytokine signalling
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- Epigenetic biomarkers of tuberculosis infection
- Epigenetics – genome wide multiplexed single-cell CUT&Tag assay development
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Exploiting the cell death pathway to fight Schistosomiasis
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- How do nutrition interventions and interruption of malaria infection influence development of immunity in sub-Saharan African children?
- Human lung protective immunity to tuberculosis
- Improving therapy in glioblastoma multiforme by activating complimentary programmed cell death pathways
- Innovating novel diagnostic tools for infectious disease control
- Integrative analysis of single cell RNAseq and ATAC-seq data
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigation of a novel cell death protein
- Malaria: going bananas for sex
- Mapping spatial variation in gene and transcript expression across tissues
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- Multi-modal computational investigation of single-cell communication in metastatic cancer
- Nanoparticle delivery of antibody mRNA into cells to treat liver diseases
- Naturally acquired immune response to malaria parasites
- Organoid-based discovery of new drug combinations for bowel cancer
- Organoid-based precision medicine approaches for oral cancer
- Removal of tissue contaminations from RNA-seq data
- Reversing antimalarial resistance in human malaria parasites
- Role of glycosylation in malaria parasite infection of liver cells, red blood cells and mosquitoes
- Screening for novel genetic causes of primary immunodeficiency
- Single-cell ATAC CRISPR screening – Illuminate chromatin accessibility changes in genome wide CRISPR screens
- Spatial single-cell CRISPR screening – All in one screen: Where? Who? What?
- Statistical analysis of single-cell multi-omics data
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- The role of ribosylation in co-ordinating cell death and inflammation
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding cellular-cross talk within a tumour microenvironment
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- Unveiling the heterogeneity of small cell lung cancer
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to understand malaria invasion and transmission
- Using structural biology to understand programmed cell death
- Validation and application of serological markers of previous exposure to malaria
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- WEHI.TV
Helping shape and build Victoria's medical research sector
Meet alum James McCoy, who is Principal Policy Officer, Medical Research with the Victorian Government’s Department of Jobs, Precincts and Regions.
James first joined WEHI as an honours student and was drawn to the projects and passion of our researchers.
“Microbiology was my favourite field during undergrad studies, and I was particularly fascinated by the incredibly complex signalling cascades which worked together to make these tiny organisms tick,” explains James.
“I recall really enjoying a lecture on malaria parasites, with their intricate subcellular architecture. I looked up who was doing exciting research related to malaria with a cell signalling focus, and Chris Tonkin’s name came up. We had a meeting, and I was immediately drawn in by the way he spoke about the malaria model organism Toxoplasma.
“It ended up being a great honours year, which led into my PhD. It was rarely easy, and often frustrating, but the sparks of success and support of people around me make those years some of my fondest memories.
“There is nothing like seeing something you know you are the first person in the world to discover. It’s incredibly rare, and takes as much blind luck as skill, but it’s truly special,” says James.
After three years as a postdoctoral researcher in Vancouver, British Columbia, James got his first taste of working in policy through the Canadian Science Policy Fellowship, which brings scientists into government to drive evidence-based policy.
Challenging but rewarding
“Moving from research to public service was very rewarding, and I was thrilled by just how interesting and engaging the work was,” he says.
“But my move definitely had its challenges. It was really jarring at first coming from science, where you’re able to work very independently, to government where there are constant checks and oversight.”
Perhaps most challenging, says James, was learning what a valuable contribution researchers can make beyond the narrow focus of their lab work.
“You may feel as if your specialised knowledge and skills are being wasted outside of the lab. However, PhDs and postdocs are also experts at project management, and analysis and synthesis of evidence. They have learned to communicate complex issues in clear, effective language, and - perhaps most importantly - are highly adaptable.”
Despite leaving hands-on science behind as a career, James remains very passionate about medical research and is able to harness that passion in his work.
“My main project is the development of an ‘action plan’ to support and enhance Victorian clinical trials,” he says. “I get to immerse myself in policy and strategy across a range of areas in Victoria’s medical research sector.”
On any given day, James can find himself providing advice on a critical issue to the Minister for Medical Research, meeting with stakeholders across the sector to gauge their opinions, or reviewing a funding proposal.
Alumni-to-PhD mentoring
Since moving back from Canada, James has had the opportunity to reconnect with fellow WEHI alumni and those with whom he completed his PhD and to learn what they’ve been up to.
He has also recently signed up as an inaugural mentor in the WEMentor alumni-to-PhD mentoring pilot.
“One thing I wish I’d had earlier was someone who could help me understand my career options,” says James. “I think having a person who you can bounce ideas off and who can give you impartial advice can be incredibly valuable in guiding your career decisions”.
In his spare time, James enjoys getting along to local gigs and catching up with friends, as well as getting outside as much as he can, whether that’s day walks, car camping or hiking. He’s also trying to re-learn the piano for the first time in nearly 20 years “…which is going about as well as you can imagine,” he quips.