ACRF Chemical Biology

ACRF Chemical Biology

Protein structure formed in the process of apoptosis
The ACRF Chemical Biology division aims to discover new medicines. 

We use structural, chemical and molecular biology approaches along with medicinal chemistry and high-throughput screening, to identify and validate novel therapeutic targets. 

Our work has relevance to a range of diseases including cancers, inflammatory diseases and infections.

Members of our division have made important contributions to a number of research areas, including our understanding of: 

  • cell death pathways
  • kinase signalling pathways 
  • protein glycosylation in diseases
  • the molecular mechanisms that contribute to malarial parasite survival

Health impact

Cancers: bowel cancer, brain cancerbreast cancer, leukaemia, lung cancer, lymphoma, myelomamyeloproliferative disordersovarian cancer, prostate cancer, rare cancers, stomach cancer

Immune health and infection: asthma, autoinflammatory diseases, Crohn’s disease, coeliac disease, HIVinflammatory bowel disease, lupus, malaria, psoriasis, rheumatoid arthritis, toxoplasmosismultiple sclerosis, vaccines

Development and ageing: heart disease and stroke, multiple sclerosis, neurodegenerative disorders, Parkinson’s disease


Division news

Division head

Associate Professor Isabelle Lucet

Lab heads

Associate Professor Ethan Goddard-Borger

Professor Guillaume Lessene

Dr Brad Sleebs

Division coordinator

Leeanne Lewis