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- A multi-pronged approach to targeting myeloproliferative neoplasms
- A new paradigm of machine learning-based structural variant detection
- A whole lot of junk or a treasure trove of discovery?
- Advanced imaging interrogation of pathogen induced NETosis
- Analysing the metabolic interactions in brain cancer
- Atopic dermatitis causes and treatments
- Boosting the efficacy of immunotherapy in lung cancer
- Building a cell history recorder using synthetic biology for longitudinal patient monitoring
- Characterisation of malaria parasite proteins exported into infected liver cells
- Deciphering the heterogeneity of the tissue microenvironment by multiplexed 3D imaging
- Defining the mechanisms of thymic involution and regeneration
- Delineating the molecular and cellular origins of liver cancer to identify therapeutic targets
- Developing computational methods for spatial transcriptomics data
- Developing drugs to block malaria transmission
- Developing models for prevention of hereditary ovarian cancer
- Developing statistical frameworks for analysing next generation sequencing data
- Development and mechanism of action of novel antimalarials
- Development of novel RNA sequencing protocols for gene expression analysis
- Discoveries in red blood cell production and function
- Discovering epigenetic silencing mechanisms in female stem cells
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Dissecting mechanisms of cytokine signalling
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- Epigenetic biomarkers of tuberculosis infection
- Epigenetics – genome wide multiplexed single-cell CUT&Tag assay development
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Exploiting the cell death pathway to fight Schistosomiasis
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- How do nutrition interventions and interruption of malaria infection influence development of immunity in sub-Saharan African children?
- Human lung protective immunity to tuberculosis
- Improving therapy in glioblastoma multiforme by activating complimentary programmed cell death pathways
- Innovating novel diagnostic tools for infectious disease control
- Integrative analysis of single cell RNAseq and ATAC-seq data
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigation of a novel cell death protein
- Malaria: going bananas for sex
- Mapping spatial variation in gene and transcript expression across tissues
- Mechanisms of Wnt secretion and transport
- Multi-modal computational investigation of single-cell communication in metastatic cancer
- Nanoparticle delivery of antibody mRNA into cells to treat liver diseases
- Naturally acquired immune response to malaria parasites
- Organoid-based discovery of new drug combinations for bowel cancer
- Organoid-based precision medicine approaches for oral cancer
- Removal of tissue contaminations from RNA-seq data
- Reversing antimalarial resistance in human malaria parasites
- Role of glycosylation in malaria parasite infection of liver cells, red blood cells and mosquitoes
- Screening for novel genetic causes of primary immunodeficiency
- Single-cell ATAC CRISPR screening – Illuminate chromatin accessibility changes in genome wide CRISPR screens
- Spatial single-cell CRISPR screening – All in one screen: Where? Who? What?
- Statistical analysis of single-cell multi-omics data
- Structural and functional analysis of epigenetic multi-protein complexes in genome regulation
- Structural basing for Wnt acylation
- Structure, dynamics and impact of extra-chromosomal DNA in cancer
- Targeted deletion of disease-causing T cells
- Targeting cell death pathways in tissue Tregs to treat inflammatory diseases
- The cellular and molecular calculation of life and death in lymphocyte regulation
- The role of hypoxia in cell death and inflammation
- The role of ribosylation in co-ordinating cell death and inflammation
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding cellular-cross talk within a tumour microenvironment
- Understanding the genetics of neutrophil maturation
- Understanding the roles of E3 ubiquitin ligases in health and disease
- Unveiling the heterogeneity of small cell lung cancer
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to understand malaria invasion and transmission
- Using structural biology to understand programmed cell death
- Validation and application of serological markers of previous exposure to malaria
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Annual reports
If you would like a hard copy or earlier annual reports, including highlights and financial statements, email communityrelations@wehi.edu.au or phone +61 3 9345 2555.
2022 Annual Report
WEHI marked another year of remarkable achievements in research, discovery, translation and collaboration in 2022, including:
- the first National Conference of The Brain Cancer Centre and the launch of a world-first perioperative brain cancer clinical trial platform (Brain-POP)
- important discoveries and advances in COVID-19, gene silencing, colon cancer, malaria and diabetes
- significant national awards and honours for deputy director Professor Alan Cowman AC, Professor Clare Scott AM and Professor Sant-Rayn Pasricha.
The 2022 Annual Report includes highlights of these achievements – with links to more extensive reports on our website – together with overviews of significant initiatives across our operations.
View the 2022 Annual Report Financial Statements.
2021 Annual Report
The 2021 Annual Report showcases an exciting year of discoveries, partnerships and organisational activity at WEHI. A few highlights include:
- the Brain Cancer Centre, founded by Carrie’s Beanies 4 Brain Cancer and established in partnership with WEHI
- the Centre for Biologic Therapies, launched by WEHI in partnership with our long-term collaborator CSL
- WEHI’s multidisciplinary response to find much-needed treatments, rapid diagnostic tools and optimal vaccine strategies for COVID-19
Our 2021 Annual Report again includes augmented reality experiences. Download the WEHI AR app to your smartphone and use it to scan the augmented reality content on the cover and elsewhere throughout the report.
Visit the WEHI AR page for further information.
2020 Annual Report
WEHI launched its new brand in 2020, heralding a bright new era for our institute. The 2020 Annual Report describes this journey as well as research highlights, including:
- WEHI's response to the COVID-19 pandemic, including the launch of a new multidisciplinary coronavirus research program.
- Progress towards better treatments for several types of cancer, as well as degenerative conditions and iron deficiency.
- The discovery of the cellular and molecular origins of different blood cell types.
Our 2020 Annual Report includes augmented reality experiences. Download the WEHI AR app to your smartphone and use it to scan the augmented reality content on the cover and elsewhere throughout the report.
Visit the WEHI AR page for further information.
2019 Annual Report
Highlights from the Institute in 2019 include:
- Implementing the first year of our Strategic Plan 2019-2023, supporting our commitment to improving the lives of those suffering from disease
- Establishing the National Drug Discovery Centre to bring medicines to patients sooner
- Anti-cancer treatment venetoclax listed on the Australian PBS
2018 Annual Report
This annual report highlights how our decade-long commitment to recruiting a new generation of scientific leaders has paid dividends.
Our scientific achievements of 2018 include:
- landmark discoveries about the molecules driving lung cancer
- studies that improve the management of coeliac disease
- discoveries providing new insights into cell biology, enabled by our Centre for Dynamic Imaging
2017 Annual Report
In 2017 our scientists led many advances in both fundamental and translational research. These include:
- progressing clinical trials in breast cancer
- explaining in more detail how the body maintains balance in the immune system for good health
- applying bioinformatics and imaging techniques to unravel the biology of a neglected parasitic disease
2016 Annual Report
The 2016 Annual Report showcases an exciting year of scientific and organisational activity at the Institute.
Several key research advances shed light on fundamental biological processes, moving us closer to better health outcomes for patients. Among these are:
- a potential new approach to breast cancer in women who carry the BRCA1 gene
- using the genome sequence of the scabies and malaria parasites to identify potential new treatment approaches
- study of cone snail venom to inform more efficient therapies for diabetes
2015 Annual Report
"If one message came from our researchers and our supporters in 2015, it was that there is great optimism and hope for all that the Institute can achieve in its second century," Institute director Professor Doug Hilton
This past year has seen advances in understanding how malaria persists in populations, the development of potential new treatments for cancers, and new insights into immune disorders, including immunodeficiencies, allergies and coeliac disease.
2014 Annual Report
This report covers only six months due to the change in financial year, to better align the Institute with the government grant cycle.
This year, in consultation with staff, students, supporters and collaborators, we have been developing a new five-year strategic plan that will follow on from our current plan, guiding our operations from 2015 to 2020.
Our researchers have made many exciting research breakthroughs this year, and have been duly rewarded with notable prizes and competitive grants.
View the Financial Statements 1 July - 31 December 2014.
2013-2014 Annual Report
The Institute's 2013-2014 Annual Report includes highlights from the previous 12 months of research, translation, education, engagement and sustainability activities at the Institute.
- Finding the cause of inflammatory disease
- Prime Minister's Prize for Science to Professor Terry Speed
- Trial results bringing high hopes for advanced leukaemia
- Viruses light White Night festival
- Acknowledging and thanking our supporters
2012-2013 Annual Report
The Institute is home to almost 750 researchers who are working to understand, prevent and treat diseases including cancer, immune disorders and infectious diseases.
Making major discoveries requires teams of researchers and clinicians who are willing to work with each other over many years while supported by stable funding. We would like to take this opportunity to thank you all and to encourage you to read this report and take pride in the work that you have allowed to happen.
Archive
Download a copy of an annual report; all files are in PDF format.