Dr Guillermo Gomez - SA Pathology & University of South Australia

Dr Guillermo Gomez - SA Pathology & University of South Australia

Location: 
Online
Start Time: 
Fri, 21/08/2020 - 1:00pm
End Time: 
Fri, 21/08/2020 - 2:00pm
 

Artificial intelligence of histopathological images reveals novel gene signatures to target the glioblastoma tumour microenvironment

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Dr Guillermo Gomez is an ARC Future Fellow and lead of the Tissue Architecture and Organ Function laboratory at the Centre for Cancer Biology, an alliance between SA Pathology and the University of South Australia, in Adelaide.

Guillermo did his PhD and his first postdoctoral position in Argentina, where he acquired experience in programing and quantitative image analysis together with live cell imaging. He then joined the laboratory of Professor Alpha Yap at the University of Queensland where they implemented novel fluorescence microscopy technologies to study the mechanobiology of cell-cell interactions and how these contribute to multicelular tissue organization. Their work, published in Nature Cell Biology (2012, 2014, 2015), thus contributed to the elucidation of the signalling pathways that control mechanical homeostasis and mechanosensing at the cell-cell junctions.
 
Now, his laboratory is applying this knowledge to understand the mechanisms that contribute cancer growth and invasion within the brain. By combining stem-cell organoid technologies and bioengineering approaches with genome-editing, multiphoton microscopy and artificial intelligence, they are developing novel assays that are useful to determine the key features that contribute to cancer stem cell plasticity and how this in cooperation with the tumour microenvironment contribute to drug resistance.