Dr Jennifer Devlin - Peter MacCallum Cancer Centre

Dr Jennifer Devlin - Peter MacCallum Cancer Centre

Location: 
Online
Start Time: 
Tue, 26/10/2021 - 1:30pm
End Time: 
Tue, 26/10/2021 - 2:00pm

Special Lecture hosted by Dr Lahiru Gangoda – Blood Cells & Blood Cancer division

Dr Jennifer Devlin

Senior Postdoctoral Research, Peter MacCallum Cancer Centre

Molecular Dissection and Therapeutic Targeting of CDKs in RNA Pol II Transcription Cycles

 

Join via TEAMS

Including Q&A session

 

The dysregulation of RNA polymerase II (Pol II) dependent transcription cycles is a hallmark of cancer, driving altered gene expression programs that initiate and sustain oncogenic phenotypes. Cancer cells consequently exhibit exquisite sensitivity to therapeutic approaches that disrupt Pol II transcription. Transcriptional cyclin-dependent-kinases (t-CDKs), including CDK7, CDK8, and CDK9 regulate progression of Pol II through transcription cycle checkpoints, and small molecule inhibitors of these kinases (t-CDKi) have demonstrated potent anti-tumor activity in a range of pre-clinical cancer models.

 

Genome-wide DNA- and RNA-sequencing and global phospho-proteomics technologies have been applied to dissect the molecular functions of tCDKs in Pol II transcription cycles. This work combines the use of unique chemical-genetic systems including analog-sensitive mutant kinases and rapid, inducible protein degradation to elucidate the molecular functions of the previously understudied t-CDKs, CDK12/CDK13 and CDK11, that are essential for cancer cell proliferation and survival.

 

All welcome!!