Dr Kim-Anh Lê Cao - The University of Melbourne

Dr Kim-Anh Lê Cao - The University of Melbourne

Location: 
Seminar Room 2
Start Time: 
Thu, 01/08/2019 - 12:00pm
End Time: 
Thu, 01/08/2019 - 1:00pm

​A holistic perspective: integration of multi-omics and microbiomes

​Special seminar hosted by Dr Sant-Rayn Pasricha

Technological improvements have allowed for the collection of data from different molecular compartments resulting in multiple omics data from the same set of biospecimens. We propose to adopt a holistic approach to glean molecular insights of a biological system.

Integrating data include numerous challenges – data are complex and large, each with few samples and many molecules, and generated using different technological platforms. We have developed a comprehensive dimension reduction multivariate framework to address some of these challenges*. In a human newborns study, we have identified multi-omics signatures composed of cytokines, transcripts, proteins and metabolites to identify characterize molecular ontogeny of the first week of life. In a recent study, we are tackling the problem of integrating omics and microbiome data from longitudinal assays.

*Our methods are implemented in the Bioconductor R package mixOmics, dedicated to omics data integration.

Dr Kim-Anh Lê Cao is an expert in multivariate statistical methods and novel developments. Since 2009, her team has been working on developing the R toolkit mixOmics that is dedicated to the integrative analysis of `omics' data, including microbiome data, to help researchers mine and make sense of biological data.