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- Associate Profesor Ian Majewski
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- A new regulator of stemness to create dendritic cell factories for immunotherapy
- Advanced methods for genomic rearrangement detection
- Control of cytokine signaling by SOCS1
- Defining the protein modifications associated with respiratory disease
- Delineating the pathways driving cancer development and therapy resistance
- Developing a new drug that targets plasmacytoid dendritic cells for the treatment of lupus
- Development and mechanism of action of novel antimalarials
- Development of a novel particle-based malaria vaccine
- Development of tau-specific therapeutic and diagnostic antibodies
- Discovering novel therapies for major human pathogens
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Epigenetic biomarkers of tuberculosis infection
- Essential role of glycobiology in malaria parasites
- Evolution of haematopoiesis in vertebrates
- Human lung protective immunity to tuberculosis
- Identifying novel treatment options for ovarian carcinosarcoma
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigating the role of mutant p53 in cancer
- Microbiome strain-level analysis using long read sequencing
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Modelling spatial and demographic heterogeneity of malaria transmission risk
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Structural basis of catenin-independent Wnt signalling
- Structure and biology of proteins essential for Toxoplasma parasite invasion
- T lymphocytes: how memories are made
- TICKER: A cell history recorder for longitudinal patient monitoring
- Targeting host pathways to develop new broad-spectrum antiviral drugs
- Targeting post-translational modifications to disrupting the function of secreted proteins
- Targeting the epigenome to rewire pro-allergic T cells
- Targeting the immune microenvironment to treat KRAS-mutant adenocarcinoma
- The E3 ubiquitin ligase Parkin and mitophagy in Parkinson’s disease
- The molecular controls on dendritic cell development
- Understanding malaria infection dynamics
- Understanding the genetics of neutrophil maturation
- Understanding the neuroimmune regulation of innate immunity
- Understanding the proteins that regulate programmed cell death at the molecular level
- Using cutting-edge single cell tools to understand the origins of cancer
- When healthy cells turn bad: how immune responses can transition to lymphoma
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Aaron Jex - Publications
Researcher:
Selected publications
- Ansell BRE, McConville MD, Ma'ayeh SY, Dagley MJ, Gasser RB, Svard SG, Jex AR. (2015). Drug resistance in Giardia duodenalis. Biotechnol Adv, 33, 888-901. PMID: 25922317
- Ansell BRE, McConnville MJ, Baker L, Korhonen PK, Young ND, Hall RS, Rojaz CAA, Svard SG, Gasser RB, Jex AR. (2015). Time-dependent transcriptional changes in axenic Giardia duodenalis trophozoites. PLoS Negl Trop Dis. DOI: 10.1371/journal.pntd.0004261 PMID: 26636323
- Zhu XQ, Korhonen P, Young ND, Huimin C, Nejsum P, von Samsom-Himmelstjerna G, Boag P, Tan P, Fang X, Hall RS, Hofmann A, Sternberg P, Jex AR and Gasser RB. (2015). Genetic blueprint of the zoonotic pathogen Toxocara canis. Nat Comms. In Press PMID: 25649139
- Jex AR, Nejsum P, Schwarz EM, Hu L, Young ND, Hall RS, Korhonen PK, Liao S, Thamsborg S, Xia J, Xu P, Wang S, Scheerlink JPY, Hofmann A, Sternberg PW, Wang J, Gasser RB. (2014). Genome and transcriptome of the porcine whipworm Trichuris suis. Nat Genetics. 46, 701-6 PMID: 24929829
- Young ND*, Jex AR*, Li B*, Liu S, Yang L, Xiong Z, Li Y, Cantacessi C, Hall RS, Xu X, Chen F, Wu X, Zerlotini A, Oliviera G, Hofmann A, Zhang G, Fang X, Kang Y, Campbell BE, Loukas A, Ranganathan S, Rollinson D, Rinaldi G, Brindley PJ, Wang Jun, Yang H, Wang Jian and Gasser RB. (2012). Whole-genome sequence of Schistosoma haematobium. Nat Genetics, 44, 221-225 PMID: 22246508
- Jex AR*, Liu S*, Li B*, Young ND*, Hall RS, Li Y, Yang L, Zeng N, Xu X, Xiong Z, Chen F, Wu X, Zhang G, Fang X, Kang Y, Anderson GA, Harris TW, Campbell BE, Vlaminck J, Wang T, Cantacessi C, Schwarz EM, Ranganathan S, Geldhof P, Nejsum P, Sternberg PW, Yang H, Wang Jun, Wang Jian and Gasser RB. (2011). Ascaris suum draft genome. Nature, 479: 529-533. PMID: 22031327
- Jex AR, Smith HV, Nolan MJ, Campbell BE, Young ND, Cantacessi C and Gasser RB. (2011). Cryptic parasite revealed – improved prospects for treatment and control of human cryptosporidiosis through advanced technologies. Adv Parasitol, 77, 141-73 PMID: 22137584
- Jex AR, Hall RS, Littlewood DT, Gasser RB. (2010) An integrated pipeline for next-generation sequencing and annotation of mitochondrial genomes. Nucleic Acids Res; 38: 522-533 PMID: 19892826
- Jex AR and Gasser RB (2010) Genetic richness and diversity in Cryptosporidium hominis and C. parvum reveals major knowledge gaps and a need for the application of "next generation" technologies - Research review. Biotechnol Adv; 28: 17-26 PMID: 19699288
- Jex AR, Smith HV, Monis P, Campbell BE, Gasser RB. (2008). Cryptosporidium - biotechnological advances in detection, diagnosis and analysis of genetic variation. Biotechnol Adv; 26: 304-317 PMID: 18430539