Brad Sleebs-Publications

Brad Sleebs-Publications


Selected publications

1.     Nguyen, W.; Dans, M. G.; Ngo, A.; Gancheva, M. R.; Romeo, O.; Duffy, S.; de Koning-Ward, T. F.; Lowes, K. N.; Jousset Sabroux, H.; Avery, V. M.; Wilson, D. W.; Gilson, P.R.; Sleebs, B.E. Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion. Eur. J. Med. Chem. 2021, 214, 113253. PMID: 33610028

2.     Nguyen, W.; Lee, E. F.; Evangelista, M.; Lee, M.; Harris, T. J.; Colman, P. M.; Williams, L. B.; Smith, N.; Lowes, K. N.; Haeberli, C.; Keiser, J.; Smith, B. J.; Fairlie, D. W.* Sleebs, B. E. Optimization of benzothiazole and thiazole hydrazones as inhibitors of schistosome BCL-2. ACS Infect. Dis. 2021, 7(5) 1143-1163. PMID: 33523649

3.     Currie, I.; Sleebs, B. E.* Synthesis of acyl phosphoramidates via a modified Staudinger reaction. Org. Lett. 2021, 23(2) 464-468. PMID: 33379864

4.     Chen H.; Mao R.; Brzozowski, M; Nguyen, N.; Sleebs, B. E.* Late stage phosphotyrosine mimetic functionalization of peptides employing a nickel-catalyzed photoredox cross-coupling. Org. Lett. 2021, 23, 11, 4244-4249. PMID: 34029466

5.     Favuzza, P.; Ruiz, M. L.; Thompson, J. K.; Triglia, T.; Ngo, A.; Steel, R. W. J.; Vavrek, M.; Christensen, J.; Healer, J.; Boyce, C.; Guo, A.; Hu, M.; Khan, T.; Murgolo, N.; Zhao, L.; Penington, J. S.; Reaksudsan, K.; Jarman, K.; Dietrich, M. H.; Richardson, L.; Guo, K.-Y.; Lopaticki, S.; Tham, W.-H.; Rottmann, M.; Papenfuss, T.; Robbins, J. A.; Boddey, J. A.; Sleebs, B. E.; Jousset Sabroux, H.; McCauley, J. A.; Olsen, D.; Cowman, A. F. Discovery of dual plasmepsin-targeting antimalarial agents that disrupt multiple stages of the malaria parasite lifecycle. Cell Host Microbe. 2020, 27, 642-658. PMID:

6.     Nguyen, W.; Jacobson, J.; Jarman, K. E.; Blackmore, T. R.; Jousset Sabroux, H.; Lewin, S. R.; Purcell, D. F.; Sleebs, B. E. Optimization of 5-substituted thiazolyl ureas and 6-substituted imidazolopyridines as potential HIV-1 latency reversing agents. Eur. J. Med. Chem. 2020, 195, 112254. PMID: 32109369

7.     Nguyen W, Jarman KE, Jacobson J, Harty L, Jousset Subroux H, Lewin S, Purcell DF, Sleebs B E. Identification of 2-amidothaizoles that activate tat mediated transcription in HIV-1 latency models. J. Med. Chem. 2019, 62 (10) 5148-5175. PMID: 30973727

8.     Gilson, P. R.;  Nguyen, W.;  Poole, W. A.;  Teixeira, J. E.;  Thompson, J. K.;  Guo, K.;  Stewart, R. J.;  Ashton, T. D.;  White, K. L.;  Sanz, L. M.;  Gamo, F.-J.;  Charman, S. A.;  Wittlin, S.;  Duffy, J.;  Tonkin, C. J.;  Tham, W.-H.;  Crabb, B. S.;  Cooke, B. M.;  Huston, C. D.;  Cowman, A. F.; Sleebs, B. E. Evaluation of 4-amino 2-anilinoquinazolines against Plasmodium and other apicomplexan parasites in vitro and in a P. falciparum humanized NOD-scid IL2Rγnull mouse model of malaria. Antimicrob. Agents Chemother.2019, 63 (3), e01804-18. PMID: 30559138

9.     Jennison, C.; Lucantoni, L.; O’Neill, M. T.; Lopaticki, S.; Cowman, A. F.; Sleebs, B. E.; Avery, V. M.; Boddey, J. A. Plasmepsin V is essential for gametocytogenesis and mosquito transmission of Malaria parasites. Cell Rep. 2019, 29 (12), 3796-3806. PMID: 31851913

10.   Nguyen W, Hodder AN, de Lezongard RB, Czabotar PE, Jarman KE, O'Neill MT, Thompson JK, Jousset Sabroux H, Cowman AF, Boddey JA, Sleebs BE. Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics. Eur. J. Med. Chem. 2018 15: 182-198. PMID: 29800827


Further publications