Selected publications

1. Gladkova C, Maslen S, Skehel LM, Komander D. Mechanism of Parkin activation by PINK1. Nature. 2018 Jul;559(7714):410-414. Epub 2018 Jun 6. PMID: 29995846
2. Schubert AF, Gladkova C, Pardon E, Steyaert J, Maslen SL, Komander D. Structure of PINK1 in complex with its substrate ubiquitin. Nature. 2017 Dec 7; 552(7683): 51-56. PMID: 29160309
3. Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Heride C, Lancia Jr. DR, Caravella JR, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy ZZ, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F , McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urbé S, Clague MJ, Kessler BM, Komander D. Molecular basis of USP7 inhibition by selective small molecule inhibitors. Nature (2017) Oct 26; 550(7677): 481-486. PMID: 29045389
4. Gersch M, Gladkova C$, Schubert AF$, Michel MA, Maslen SL, Komander D. Mechanism and regulation of the Lys6-selective deubiquitinase USP30. Nat Struct Mol Biol. 2017 Nov; 24(11): 920-930. PMID: 28945249
5. Mevissen TET, Kulathu Y, Mulder MPC, Geurink PP, Maslen SL, Gersch M, Elliott PR, Burke JE, van Tol BDM, Akutsu M, El Oualid F, Kawasaki M, Freund SMV, Ovaa H and Komander D. Molecular basis for Lys11-polyubiquitin specificity in Cezanne/OTUD7B. Nature. 2016 Oct 20; 538(7625): 402-405. PMID: 27732584
6. Damgaard RB, Walker JA, Marco-Casanova P, Morgan NV, Titheradge HL, Elliott PR, McHale D, Maher ER, McKenzie ANJ, Komander D. The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity. Cell. 2016 Aug 25; 166(5): 1215-1230. Epub Aug 11 PMID: 27523608
7. Wauer T, Simicek M, Schubert A, Komander D. Mechanism of phospho-ubiquitin induced Parkin activation. Nature. 2015 Aug 20; 524(7565): 370-4. PMID: 26161729
8. Mevissen TET, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SMV, Ovaa H, Komander D. OTU domain deubiquitinases reveal mechanisms of linkage-specificity and enable ubiquitin chain restriction analysis. Cell. 2013 Jul 3; 154(1): 169-84. PMID: 23827681
9. Keusekotten K, Elliott PR, Glockner L, Fiil BK, Damgaard RB, Kulathu Y, Wauer T, Hospenthal MK, Gyrd-Hansen M, Krappmann D, Hofmann K, Komander D. OTULIN antagonizes LUBAC ignalling by specifically hydrolysing Met1-linked polyubiquitin. Cell. 2013 Jun 6; 153(6): 1312-26 PMID: 23746843

Further publications