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- A new regulator of stemness to create dendritic cell factories for immunotherapy
- Advanced methods for genomic rearrangement detection
- Control of cytokine signaling by SOCS1
- Defining the protein modifications associated with respiratory disease
- Delineating the pathways driving cancer development and therapy resistance
- Developing a new drug that targets plasmacytoid dendritic cells for the treatment of lupus
- Development and mechanism of action of novel antimalarials
- Development of a novel particle-based malaria vaccine
- Discovering novel therapies for major human pathogens
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Epigenetic biomarkers of tuberculosis infection
- Essential role of glycobiology in malaria parasites
- Evolution of haematopoiesis in vertebrates
- Human lung protective immunity to tuberculosis
- Identifying novel treatment options for ovarian carcinosarcoma
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigating the role of mutant p53 in cancer
- Microbiome strain-level analysis using long read sequencing
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Modelling spatial and demographic heterogeneity of malaria transmission risk
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Structural basis of catenin-independent Wnt signalling
- Structure and biology of proteins essential for Toxoplasma parasite invasion
- T lymphocytes: how memories are made
- TICKER: A cell history recorder for longitudinal patient monitoring
- Targeting host pathways to develop new broad-spectrum antiviral drugs
- Targeting post-translational modifications to disrupting the function of secreted proteins
- Targeting the epigenome to rewire pro-allergic T cells
- Targeting the immune microenvironment to treat KRAS-mutant adenocarcinoma
- The E3 ubiquitin ligase Parkin and mitophagy in Parkinson’s disease
- The molecular controls on dendritic cell development
- Understanding malaria infection dynamics
- Understanding the genetics of neutrophil maturation
- Understanding the neuroimmune regulation of innate immunity
- Understanding the proteins that regulate programmed cell death at the molecular level
- Using cutting-edge single cell tools to understand the origins of cancer
- When healthy cells turn bad: how immune responses can transition to lymphoma
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Doug Hilton-Publications
Researcher:
Publications
- Gearing DP, Gough NM, King JA, HILTON DJ, Nicola NA, Simpson RJ, Nice EC, Kelso A, Metcalf D. Molecular cloning and expression of cDNA encoding a murine myeloid leukemia-inhibitory factor (LIF). EMBO J 6: 3995-4002, 1987. PMID: 3127201
- HILTON DJ, Nicola NA, Metcalf D. Purification of a murine leukemia inhibitory factor from Krebs Ascites cells. Anal Biochem 173: 359-67, 1988. PMID: 3142300
- HILTON DJ, Nicola NA, Metcalf D. Specific binding of murine leukemia inhibitory factor to normal and leukemic monocytic cells. Proc Natl Acad Sci USA 85: 5971-5, 1988. PMID: 3137563
- Williams RL, HILTON DJ, Pease S, Willson TA, Stewart CL, Gearing DP, Wagner EF, Metcalf D, Nicola NA, Gough NM. Myeloid leukemia inhibitory factor (LIF) maintains the developmental potential of embryonic stem cells. Nature 336: 684-7, 1988. PMID: 3143916
- HILTON DJ. LIF: Lots of interesting functions. Trends Biochem Sci 17: 72-6, 1992. PMID:1566332
- HILTON DJ, Hilton AA, Raicevic A, Rakar S, Harrison-Smith M, Gough NM, Begley CG, Metcalf D, Nicola NA, Willson TA. Cloning of a murine IL-11 receptor alpha chain; requirement of gp130 for high affinity binding and signal transduction. EMBO J 13: 4765-75, 1994. PMID: 7957045
- HILTON DJ, Watowich SS, Murray PJ, Lodish HF. Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor. Proc Natl Acad Sci USA 92: 190-4, 1995. PMID: 7816815
- HILTON DJ, Zhang J-G, Metcalf D, Alexander W, Nicola NA, Willson TA. Cloning and characterization of a binding subunit of the interleukin-13 receptor that is also a component of the interleukin-4 receptor. Proc Natl Acad Sci USA 93: 497-501, 1996. PMID: 8552669
- Starr R, Willson TA, Viney EM, Murray LJL, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, HILTON DJ. A family of cytokine-inducible inhibitors of signalling. Nature 387: 917-21, 1997. PMID: 9202125
- HILTON DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci USA 95: 114-9, 1998. PMID: 9419338
- Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, Kay TWH, Nicola NA, Hertzog PJ, Metcalf D, HILTON DJ. SOCS1 is a critical inhibitor of interferon gamma signalling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98: 597-608, 1999. PMID: 10490099
- Zhang J-G, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson, RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SBH, Alexander WS, Metcalf D, HILTON DJ, Nicola NA, Baca M. The conserved SOCS box motif in suppressors of cytokine signalling binds to elongins B and C and may couple proteins to proteasomal degradation. Proc Natl Acad Sci USA 96: 2071-6, 1999. PMID: 10051596
- Metcalf D, Greenhalgh CJ, Viney E, Willson T, Nicola NA, HILTON DJ, Alexander WS. Gigantism in mice lacking suppressor of cytokine signaling-2. Nature 405: 1069-73, 2000. PMID: 10890450
- Roberts AW, Robb L, Rakar S, Hartley L, Cluse L, Nicola NA, Metcalf D, HILTON DJ, Alexander WS. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Natl Acad Sci USA 98: 9324-9, 2001. PMID: 11481489
- Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HME, HILTON DJ. The SOCS box: a tale of destruction and degradation. Trends Biochem Sci 27: 235-41, 2002. PMID: 12076535
- Carpinelli MR*, HILTON DJ*, Metcalf D, Antonchuk JL, Hyland CD, Mifsud SL, Di Rago L, Hilton AA, Willson TA, Roberts AW, Ramsay RG, Nicola NA, Alexander WS. Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci USA 101: 6553-8, 2004 (* joint first authors). PMID: 15071178
- Alexander WS and HILTON DJ. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Ann Rev Immunol 22: 503-29, 2004. PMID: 15032587
- Loughran SJ, Kruse EA, Hacking DF, de Graaf CA, Hyland CD, Willson TA, Henley KJ, Ellis S, Voss AK, Metcalf D, HILTON DJ*, Alexander WS*, Kile BT.* The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol 9: 810-819, 2008 (* joint senior authors). PMID: 18500345
- De Graaf CA, Kauppi M, Baldwin T, Hyland C, Metcalf D, Willson TA, Carpinelli MR, Smyth GK, Alexander WS, Pimanda JE, Hilton DJ. Regulation of hematopoietic stem cells by their mature progeny. Proc Natl Acad Sci USA 107: 21689-94, 2010. PMID: 21115812
- Taoudi S, Bee T, Hilton A, Kenzevic K, Scott J, Willson TA, Collin C, Thomas T, Voss AK, Kile BT, Alexander WS, Pimanda JE, Hilton DJ. ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification. Genes Dev 25: 251-62, 2011. PMID: 21245161
- Masters SL, Gerlic M, Metcalf D, Preston S, Pellegrini M, O’Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ, Cengia LH, Henley KJ, Collinge JE, Kastner DL, Feigenbaum L, Hilton DJ, Alexander WS, Kile BT, Croker BA. NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity 37: 1009-23, 2012. PMID: 23219391
- Ng AP, Kauppi M, Metcalf D, Hyland CD, Josefsson EC, Lebois M, Zhang JG, Baldwin TM, Di Rago L, Hilton DJ, Alexander WS. Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation. Proc Natl Acad Sci USA 111: 5884-9, 2014. PMID: 24711413
- Potts KS, Sargeant TJ, Markham JF, Shi W, Biben C, Josefsson EC, Whitehead LW, Rogers KL, Liakhovitskaia A, Smyth GK, Kile BT, Medvinsky A, Alexander WS, Hilton DJ, Taoudi S. A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo. Blood 2014 Jul 25. pii: blood-2014-02-559468. PMID: 25079356
- de Graaf CA, Choi J, Baldwin TM, Bolden JE, Fairfax KA, Robinson AJ, Biben , Morgan C, Ramsay K, Ng AP, Kauppi M, Kruse EA, Sargeant TJ, Seidenman N, D'Amico A, D'Ombrain MC, Lucas EC, Koernig S, Baz Morelli A, Wilson MJ, Dower SK, Williams B, Heazlewood SY, Hu Y, Nilsson SK, Wu L, Smyth GK, Alexander WS, Hilton DJ. Haemopedia: an expression atlas of murine hematopoietic cells. Stem Cell Reports. 2016 Sep 13;7(3):571-582. PMID: 27499199
- Lemieux S, Sargeant T, Laperrière D, Ismail H, Boucher G, Rozendaal M, Lavallée VP, Ashton-Beaucage D, Wilhelm B, Hébert J, Hilton DJ, Mader S, Sauvageau G. MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets. Nucleic Acids Res. 2017 Jul 27;45(13):e122. PMID: 28472340