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- A new regulator of stemness to create dendritic cell factories for immunotherapy
- Advanced methods for genomic rearrangement detection
- Control of cytokine signaling by SOCS1
- Defining the protein modifications associated with respiratory disease
- Delineating the pathways driving cancer development and therapy resistance
- Developing a new drug that targets plasmacytoid dendritic cells for the treatment of lupus
- Development and mechanism of action of novel antimalarials
- Development of a novel particle-based malaria vaccine
- Development of tau-specific therapeutic and diagnostic antibodies
- Discovering novel therapies for major human pathogens
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Epigenetic biomarkers of tuberculosis infection
- Essential role of glycobiology in malaria parasites
- Evolution of haematopoiesis in vertebrates
- Human lung protective immunity to tuberculosis
- Identifying novel treatment options for ovarian carcinosarcoma
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigating the role of mutant p53 in cancer
- Microbiome strain-level analysis using long read sequencing
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Modelling spatial and demographic heterogeneity of malaria transmission risk
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Structural basis of catenin-independent Wnt signalling
- Structure and biology of proteins essential for Toxoplasma parasite invasion
- T lymphocytes: how memories are made
- TICKER: A cell history recorder for longitudinal patient monitoring
- Targeting host pathways to develop new broad-spectrum antiviral drugs
- Targeting post-translational modifications to disrupting the function of secreted proteins
- Targeting the epigenome to rewire pro-allergic T cells
- Targeting the immune microenvironment to treat KRAS-mutant adenocarcinoma
- The E3 ubiquitin ligase Parkin and mitophagy in Parkinson’s disease
- The molecular controls on dendritic cell development
- Understanding malaria infection dynamics
- Understanding the genetics of neutrophil maturation
- Understanding the neuroimmune regulation of innate immunity
- Understanding the proteins that regulate programmed cell death at the molecular level
- Using cutting-edge single cell tools to understand the origins of cancer
- When healthy cells turn bad: how immune responses can transition to lymphoma
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Ian Wicks-Projects
Researcher:
Cytokines and cytokine signaling in rheumatoid arthritis
Rheumatoid arthritis (RA) is a common human inflammatory disease that targets synovial joints, causing chronic joint pain and leading to significant disability. The autoantigens that trigger RA remain unclear, although activation of innate and adaptive immune systems and production of cytokines are prominent features of RA. Our laboratory aims to understand dysregulation of cytokine production and signaling in RA and to identify new therapeutic targets and biomarkers to more effectively treat RA. Prof Wicks is currently the head of the Rheumatology Unit at The Royal Melbourne Hospital, and therefore his laboratory is well placed for translational research.
Team members: Dr Simon Chatfield, Dr Gabby Goldberg, Dr Devi Ngo
New therapeutic targets in systemic lupus erythematous
Systemic lupus erythematous (SLE) is an autoimmune disease in which the connective tissues are targeted. It can result in damage to the skin, kidney and brain, and other major organs, such as the bone marrow. Current treatments, including steroids and conventional immunosuppressive agents, are often inadequate and may have toxic side effects. Our laboratory is interested in identifying new targets for treatment of SLE. We are evaluating cytokine antagonism as a new potential therapeutic approach to SLE, including a collaboration with CSL on a novel monoclonal antibody.
Team member: Dr Shereen Oon
Kawasaki disease
Kawasaki Disease (KD) is a leading cause of acquired paediatric heart disease. We have established an experimental model of KD . Current treatment for KD relies on immunoglobulin purified from blood donors, which is effective in most cases, but some children do not respond. Through the use of genetic and pharmacological approaches in our Candida albicans model we seek to determine which cytokines and inflammatory mediators are the most suitable candidates for therapeutic intervention. Ultimately this may translate into more effective treatment for KD.
Team members: Dr Angus Stock, paediatric rheumatologist at The Royal Children’s Hospital