Selected publications

1. Patel O, Roy MJ, Kropp A, Hardy JM, Dai W, Lucet IS. Structural basis for small molecule targeting of Doublecortin like kinase 1 with DCLK1-IN-1.  Commun Biol 2021 4(1):1105. DOI: 10.1038/s42003-021-02631-y PMID: 34545159

2. Liang LY, Roy M, Horne CR, Sandow JJ, Surudoi M, Dagley LF, Young SN, Dite T, Babon JJ, Janes PW, Patel O, Murphy JM, Lucet IS. The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs. Biochem J. 2021 Sep 17;478(17):3351-3371. doi: 10.1042/BCJ20210572. PMID: 34431498

3. Patel O, Roy MJ, Murphy JM, Lucet IS. The PEAK family of pseudokinases, their role in cell signalling and cancer. FEBS J. 2020 Oct;287(19):4183-4197. doi: 10.1111/febs.15087. PMID: 31599110 

4. Liang LY, Patel O, Janes PW, Murphy JM, Lucet IS. Eph receptor signalling: from catalytic to non-catalytic functions. Oncogene. 2019 Sep;38(39):6567-6584. doi: 10.1038/s41388-019-0931-2. PMID: 31406248

5. Roy MJ, Winkler S, Hughes SJ, Whitworth C, Galant M, Farnaby W, Rumpel K and Ciulli A. SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate. ACS Chem Biol. 2019 Mar 15;14(3):361-368. PMID: 30721025.

6. Patel O, Griffin MDW, Panjikar S, Dai W, Ma X, Chan H, Zheng C, Kropp A, Murphy JM, Daly RJ, Lucet IS. Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association. Nature Communications, 2017 Oct 27;8(1):1157. doi: 10.1038/s41467-017-01279-9. PMID: 29079850

7. Patel O, Dai W, Mentzel M, Griffin MD, Serindoux J, Gay Y, Fischer S, Sterle S, Kropp A, Burns CJ, Ernst M, Buchert M, Lucet IS. Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1. Structure. 2016 Sep 6;24(9):1550-61. doi: 10.1016/j.str.2016.07.008. PMID: 27545623

​More publications