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- 6 cysteine proteins key mediators between malaria parasites and human host
- A balancing act of immunity: autoimmunity versus malignancies
- Analysing single cell technologies to understand breast cancer
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- Deciphering biophysical changes in red blood cell membrane during malaria parasite infection
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- Enabling deubiquitinase drug discovery
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- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
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- How the epigenetic regulator SMCHD1 works and how to target it to treat disease
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- Investigating microbial natural products with anti-protozoal activity
- Investigating the role of mutant p53 in cancer
- Investigating the role of platelets in motor neuron disease
- Mapping DNA repair networks in cancer
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- New approaches to treat cancer and inflammatory disease using the ubiquitin system
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- Novel cell death and inflammatory modulators in lupus
- Programming T cells to defend against infections
- Restraining cytokine-receptor signalling in myeloproliferative neoplasms
- Screening for regulators of jumping genes
- Statistical analysis of genome-wide chromatin organisation using Hi-C
- Statistical analysis of trapped-ion-mobility time-of-flight mass spectrometry proteomics data
- Structure and function of E3 ubiquitin ligases
- Target identification of potent antimalarial agents
- The mitochondrial TOM complex in neurodegenerative disease
- The molecular mechanisms underlying Kir4.1 activity in gliomas
- The role of differential splicing in the genesis of breast cancer
- Uncovering the roles of long non-coding RNAs in human bowel cancer
- Understanding malaria infection dynamics
- Understanding the molecular basis of chromosome instability in gastric cancer
- Utilising pre-clinical models to discover novel therapies for tuberculosis
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Jeff Babon-Publications
Researcher:
Selected publications
- Kershaw, NJ, Laktyushin, A, et al. Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates. Growth Factors. 2014 Feb;32(1):1-10. PMID: 24438103.
- Babon, JJ, Varghese, LN, et al. Inhibition of IL-6 family cytokines by SOCS3. Semin Immunol. 2014 Feb;26(1):13-19. PMID: 24418198.
- Varghese, LN, Ungureanu, D, et al. Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses. Biochem J. 2013 Dec 19. PMID: 24354892.
- Muniz, JRC, Guo, KD, et al. Molecular Architecture of the Ankyrin SOCS Box Family of CuI5-Dependent E3 Ubiquitin Ligases. Journal of Molecular Biology. 2013 Sep 9;425(17):3166-3177. PMID: 23806657.
- Kershaw, NJ, Murphy, JM, et al. SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nature Structural & Molecular Biology. 2013 Apr;20(4):469-476. PMID: 23454976.
- Babon, JJ and Nicola, NA. The biology and mechanism of action of suppressor of cytokine signaling 3. Growth Factors. 2012 Aug;30(4):207-219. PMID: 22574771.
- Babon, JJ, Kershaw, NJ, et al. Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity. Immunity. 2012 Feb 24;36(2):239-250. PMID: 22342841.
- Babon, JJ, Sabo, JK, et al. The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression. J Mol Biol. 2009 Mar 20;387(1):162-174. PMID: 19385048.
- Babon, JJ, Sabo, JK, et al. The SOCS box domain of SOCS3: Structure and interaction with the elonginBC-cullin5 ubiquitin ligase. Journal of Molecular Biology. 2008 Sep;381(4):928-940. PMID: WOS:000258971300011.
- Babon, JJ, McManus, EJ, et al. The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. Mol Cell. 2006 Apr 21;22(2):205-216. PMID: 16630890.
