Selected publications

1. Kershaw, NJ, Laktyushin, A, et al. Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates. Growth Factors. 2014 Feb;32(1):1-10. PMID: 24438103.
2. Babon, JJ, Varghese, LN, et al. Inhibition of IL-6 family cytokines by SOCS3. Semin Immunol. 2014 Feb;26(1):13-19. PMID: 24418198.
3. Varghese, LN, Ungureanu, D, et al. Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses. Biochem J. 2013 Dec 19. PMID: 24354892.
4. Muniz, JRC, Guo, KD, et al. Molecular Architecture of the Ankyrin SOCS Box Family of CuI5-Dependent E3 Ubiquitin Ligases. Journal of Molecular Biology. 2013 Sep 9;425(17):3166-3177. PMID: 23806657.
5. Kershaw, NJ, Murphy, JM, et al. SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nature Structural & Molecular Biology. 2013 Apr;20(4):469-476. PMID: 23454976.
6. Babon, JJ and Nicola, NA. The biology and mechanism of action of suppressor of cytokine signaling 3. Growth Factors. 2012 Aug;30(4):207-219. PMID: 22574771.
7. Babon, JJ, Kershaw, NJ, et al. Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity. Immunity. 2012 Feb 24;36(2):239-250. PMID: 22342841.
8. Babon, JJ, Sabo, JK, et al. The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression. J Mol Biol. 2009 Mar 20;387(1):162-174. PMID: 19385048.
9. Babon, JJ, Sabo, JK, et al. The SOCS box domain of SOCS3: Structure and interaction with the elonginBC-cullin5 ubiquitin ligase. Journal of Molecular Biology. 2008 Sep;381(4):928-940. PMID: WOS:000258971300011.
10. Babon, JJ, McManus, EJ, et al. The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. Mol Cell. 2006 Apr 21;22(2):205-216. PMID: 16630890.