Selected publications​

1.  Doggett K, Morgan KJ, Mieruszynski S, Williams BB, Olthof AM, Garnham AL; Milevskiy MJG, Whitehead L, Coates J, Buchert M, Robert JJ O'Donoghue RJJ, Hall TE, Gong Z, Putoczki TL, Ernst M, Sutherland KD, Kanadia RN, Heath JK. The minor spliceosome offers a therapeutically viable target for the treatment of a broad spectrum of cancers. BioRxiv 2021 doi: https://doi.org/10.1101/2021.12.09.469623

2.  Morgan KJ, Doggett K, Geng FS, Whitehead L, Smith KA, Hogan BM, Simons C, Baillie GJ, Molania R, Papenfuss AT, Hall TE, Ober EA, Stainier DYR, Gong Z, Heath JK, Elys deficiency constrains Kras-driven tumour burden by amplifying oncogenic stress. BioRxiv doi: https://doi.org/10.1101/2021.08.25.457580

3. Olthof  AM, White AK ,  Mieruszynski S,  Doggett K, Lee MF , Chakroun A , Abdel Aleem AK, Rousseau J, Magnani C, Roifman CM, Campeau PM, Heath JK, Kanadia RN. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Nucleic Acids Research 49 (6), 3524-3545. PMID: 33660780

4. Doggett K, Williams BB, Markmiller S, Geng FS, Coates J, Mieruszynski S, Ernst M, Thomas T, Heath JK. Early developmental arrest and impaired gastrointestinal homeostasis in U12-dependent splicing-defective Rnpc3-deficient mice. RNA 2018:24 1856-1870. PMID: 30254136

5.  Kim EJY, Anko ML, Flensberg C, Majewski IJ, Geng FS, Firas J, Huang DCS, van Delft MF, Heath JK. BAK/BAX-mediated apoptosis is a Myc-induced roadblock to reprogramming. Stem Cell Reports. 2018 Jan 17. pii: S2213-6711(17)30567-2. doi: 10.1016/j.stemcr.2017.12.019. PMID: 29358089

6.  Lobert VH, Mouradov D, Heath JK. Focusing the spotlight on the zebrafish intestine to illuminate mechanisms of colorectal cancer. Adv Exp Med Biol. 2016;916:411-37. doi: 10.1007/978-3-319-30654-4_18. Review. PMID: 27165364

7.  Williams BB, Tebbutt NC, Buchert M, Putoczki TL, Doggett K, Bao S, Johnstone CN, Masson F, Hollande F, Burgess AW, Scott AM, Ernst M, Heath JK. Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease. Dis Model Mech. 2015 Aug 1;8(8):805-15. PMID: 26035389

8.  Markmiller S, Cloonan N, Lardelli RM, Doggett K, Keightley MC, Boglev Y, Trotter AJ, Ng AY, Wilkins SJ, Verkade H, Ober EA, Field HA, Grimmond SM, Lieschke GJ, Stainier DY, Heath JK. Minor class splicing shapes the zebrafish transcriptome during development. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3062-7. PMID: 24516132

9.  Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, Nguyen P, Preaudet A, Farid R, Edwards K, Boglev Y, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Heath JK, Sieber OM, Pleines I, Kile BJ, Nash A, Greten FR, McKenzie BS, Ernst M. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell 2013 Aug 12;24(2):257-71. PMID: 23948300

10.  Boglev Y, Badrock AP, Trotter AJ, Du Q, Richardson EJ, Parslow AC, Markmiller SJ, Hall NE, de Jong-Curtain TA, Ng AY, Verkade H, Ober EA, Field HA, Shin D, Shin CH, Hannan KM, Hannan RD, Pearson RB, Kim SH, Ess KC, Lieschke GJ, Stainier DY, Heath JK. Autophagy induction is a tor- and tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis. PLoS Genet. 2013 Feb;9(2):e1003279. PMID: 23408911

Further publications