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- A new regulator of stemness to create dendritic cell factories for immunotherapy
- Advanced methods for genomic rearrangement detection
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- Defining the protein modifications associated with respiratory disease
- Delineating the pathways driving cancer development and therapy resistance
- Developing a new drug that targets plasmacytoid dendritic cells for the treatment of lupus
- Development and mechanism of action of novel antimalarials
- Development of a novel particle-based malaria vaccine
- Development of tau-specific therapeutic and diagnostic antibodies
- Discovering novel therapies for major human pathogens
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- Essential role of glycobiology in malaria parasites
- Evolution of haematopoiesis in vertebrates
- Human lung protective immunity to tuberculosis
- Identifying novel treatment options for ovarian carcinosarcoma
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigating the role of mutant p53 in cancer
- Microbiome strain-level analysis using long read sequencing
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Modelling spatial and demographic heterogeneity of malaria transmission risk
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Structural basis of catenin-independent Wnt signalling
- Structure and biology of proteins essential for Toxoplasma parasite invasion
- T lymphocytes: how memories are made
- TICKER: A cell history recorder for longitudinal patient monitoring
- Targeting host pathways to develop new broad-spectrum antiviral drugs
- Targeting post-translational modifications to disrupting the function of secreted proteins
- Targeting the epigenome to rewire pro-allergic T cells
- Targeting the immune microenvironment to treat KRAS-mutant adenocarcinoma
- The E3 ubiquitin ligase Parkin and mitophagy in Parkinson’s disease
- The molecular controls on dendritic cell development
- Understanding malaria infection dynamics
- Understanding the genetics of neutrophil maturation
- Understanding the neuroimmune regulation of innate immunity
- Understanding the proteins that regulate programmed cell death at the molecular level
- Using cutting-edge single cell tools to understand the origins of cancer
- When healthy cells turn bad: how immune responses can transition to lymphoma
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Marc Pellegrini-publications
Researcher:
Publications
- Cross, GB, Coles, K, Nikpour, M, Moore, OA, Denholm, J, McBryde, ES, Eisen, DP, Warigi, B, Carter, R, Pandey, S, Harino, P, Siba, P, Coulter, C, Mueller, I, Phuanukoonnon, S & Pellegrini, M TB incidence and characteristics in the remote gulf province of Papua New Guinea: a prospective study. BMC Infect Dis. 2014 Feb;14:93 PMID:3936911
- Pellegrini, M & Walker, BD Host pathogen interactions at the coalface of immunity. Curr Opin Immunol 2013 Aug 25:425-7 PMID: 23790534
- Lin, AE, Ebert, G, Ow, Y, Preston, SP, Toe, JG, Cooney, JP, Scott, HW, Sasaki, M, Saibil, SD, Dissanayake, D, Kim, RH, Wakeham, A, You-Ten, A, Shahinian, A, Duncan, G, Silvester, J, Ohashi, PS, Mak, TW & Pellegrini, M ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system. Nat Immunol. 2013 Jan;14:27-33 PMID:23179078
- Pellegrini, M, Calzascia, T, Toe, JG, Preston, SP, Lin, AE, Elford, AR, Shahinian, A, Lang, PA, Lang, KS, Morre, M, Assouline, B, Lahl, K, Sparwasser, T, Tedder, TF, Paik, JH, Depinho, RA, Basta, S, Ohashi, PS & Mak, TW IL-7 Engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 2011 Feb;144:601-613 PMID: 21295337
- Pellegrini, M, Calzascia, T, Elford, AR, Shahinian, A, Lin, AE, Dissanayake, D, Dhanji, S, Nguyen, LT, Gronski, MA, Morre, M, Assouline, B, Lahl, K, Sparwasser, T, Ohashi, PS & Mak, TW Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med. 2009 May;15:528-536 PMID: 19396174
- Calzascia, T, Pellegrini, M, Lin, A, Garza, KM, Elford, AR, Shahinian, A, Ohashi, PS & Mak, TW CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc Natl Acad Sci U S A. 2008 Feb;105:2999-3004 PMID: 18287017
- Pellegrini, M, Bath, S, Marsden, VS, Huang, DC, Metcalf, D, Harris, AW & Strasser, A FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells. Blood 2005 Sep;106:1581-1589 PMID: 15905188
- Pellegrini, M, Bouillet, P, Robati, M, Belz, GT, Davey, GM & Strasser, A Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice. J Exp Med 2004 Nov;200:1189-1195 PMID:2211860
- Pellegrini, M, Belz, G, Bouillet, P & Strasser, A Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci U S A 2003 Nov;100:14175-14180 PMID: 14623954
- Bouillet, P, Purton, JF, Godfrey, DI, Zhang, L-C, Coultas, L, Puthalakath, H, Pellegrini, M, Cory, S, Adams, JM & Strasser, A BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 2002 Feb;415:922-926 PMID: 11859372
Super Content:
Professor Marc Pellegrini discusses the threat of antibiotic resistant bacteria.