Marie-Liesse Asselin-Labat-Projects

Marie-Liesse Asselin-Labat-Projects

Projects

Epigenetic regulators of lung development

Epigenetic regulation plays a critical role in lineage specification during embryonic development. We have identified chromatin-remodeling factors that are important regulators of lung development and are further exploring their role using genetically modified laboratory models. 

Development of lung cancer patient-derived xenografts as preclinical models to study novel therapeutic strategies

Among all cancers, lung cancer and melanoma, have the highest rate of mutation. To recapitulate the complexity and heterogeneity of the human disease, we have generated patient-derived xenograft models of lung cancer that recapitulate the histological phenotype of patients’ tumour.

Genomic characterisation of our model is ongoing. These models will be used to evaluate novel therapeutic approaches for lung cancer. 

Mechanisms of DNA damage repair and lung disease

Using human lung tissue samples, we aim to determine how different lung cell types respond to DNA damage. We study how these repair mechanisms are involved in the formation of adult lung disease such as lung cancer and pulmonary fibrosis.