Marie-Liesse Asselin-Labat-Projects

Marie-Liesse Asselin-Labat-Projects


Mechanisms of DNA damage repair and lung disease

Using human lung tissue samples, we aim to determine how different lung cell types respond to DNA damage. We study how these repair mechanisms are involved in the formation of adult lung disease such as lung cancer and pulmonary fibrosis.

Understanding the interactions between tumour cells and their microenvironment in non-small cell lung cancer

Mechanisms of resistance to immunotherapy include tumour intrinsic and extrinsic factors mediated by the tumour microenvironment. The project aims to characterise the interactions between immune cells and tumour cells in NSCLC to understand resistance mechanisms and propose new targets for the development of therapy.  

The project will combine single cell profiling and in situ imaging analysis with genetic studies in preclinical models of NSCLC and in clinical samples.