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- Associate Professor Justin Boddey
- Associate Professor Kate Sutherland
- Associate Professor Marie-Liesse Asselin-Labat
- Associate Professor Matthew Ritchie
- Associate Professor Melissa Call
- Associate Professor Melissa Davis
- Associate Professor Misty Jenkins
- Associate Professor Nawaf Yassi
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- Associate Professor Peter Czabotar
- Associate Professor Rachel Wong
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- Diseases
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- A new regulator of 'stemness' to create dendritic cell factories for immunotherapy
- Advanced imaging interrogation of pathogen induced NETosis
- Cancer driver deserts
- Cryo-electron microscopy of Wnt signalling complexes
- Deciphering the heterogeneity of breast cancer at the epigenetic and genetic levels
- Developing drugs to block malaria transmission
- Developing new computational tools for CRISPR genomics to advance cancer research
- Developing novel antibody-based methods for regulating apoptotic cell death
- Discovering novel paradigms to cure viral and bacterial infections
- Discovery and targeting of novel regulators of transcription
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Do membrane forces govern assembly of the deadly apoptotic pore?
- Doublecortin-like kinases, drug targets in cancer and neurological disorders
- E3 ubiquitin ligases in neurodegeneration, autoinflammation and cancer
- Engineering improved CAR-T cell therapies
- Epigenetic biomarkers of tuberculosis infection
- Exploiting cell death pathways in regulatory T cells for cancer immunotherapy
- Finding treatments for chromatin disorders of intellectual disability
- Functional epigenomics in human B cells
- Genomic rearrangement detection with third generation sequencing technology
- How does DNA damage shape disease susceptibility over a lifetime?
- How does DNA hypermutation shape the development of solid tumours?
- How platelets prevent neonatal stroke
- Human lung protective immunity to tuberculosis
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigating the role of dysregulated Tom40 in neurodegeneration
- Investigating the role of mutant p53 in cancer
- Lupus: proteasome inhibitors and inflammation
- Machine learning methods for somatic genome rearrangement detection
- Malaria: going bananas for sex
- Measurements of malaria parasite and erythrocyte membrane interactions using cutting-edge microscopy
- Measuring susceptibility of cancer cells to BH3-mimetics
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Mutational signatures of structural variation
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Revealing the epigenetic origins of immune disease
- Reversing antimalarial resistance in human malaria parasites
- Structural and functional analysis of DNA repair complexes
- Targeting human infective coronaviruses using alpaca antibodies
- Towards targeting altered glial biology in high-grade brain cancers
- Uncovering the real impact of persistent malaria infections
- Understanding Plasmodium falciparum invasion of red blood cells
- Understanding how malaria parasites sabotage acquisition of immunity
- Understanding malaria infection dynamics
- Understanding the mechanism of type I cytokine receptor activation
- Unveiling the heterogeneity of small cell lung cancer
- Using alpaca antibodies to understand malaria invasion and transmission
- Using combination immunotherapy to tackle heterogeneous brain tumours
- Using intravital microscopy for immunotherapy against brain tumours
- Using nanobodies to cross the blood brain barrier for drug delivery
- Using structural biology to understand programmed cell death
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Melissa Call-publications
Researcher:
Selected publications
- Bridgford JL, Lee SM, Lee CMM, Guglielmelli P, Rumi E, Pietra D, Wilcox S, Chhabra Y, Rubin AF, Cazzola M, Vannucchi AM, Brooks AJ, Call ME*, Call MJ*. Novel Drivers and Modifiers of MPL-dependent Oncogenic Transformation Identified by Deep Mutational Scanning. Blood. 2020 Jan 23;135(4):287-292. doi: 10.1182/blood.2019002561 PMID: 31697803
- Tan C, Byrne EFX, Ah-Cann C, Call MJ*, Call ME*. A serine the first transmembrane domain of the human E3 ubiquitin ligase MARCH9 is critical for down-regulation of its protein substrates. J Biol Chem. 2019 294(7):2470-2485. PMID: 30554144
- Park S, Krshnan L, Call MJ, Call ME*, Im W*. Structural conservation and effects of alterations in T cell receptor transmembrane interfaces. Biophys J. 2018 Mar 13;114(5):1030-1035 PMID: 29395047
- Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science. 2018 Jan 5;359(6371):48-55. PMID: 29302006
- Blázquez-Moreno A, Park S, Im W, Call MJ, Call ME*, Reyburn HT*. Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5645-E5654 PMID: 28652325
- Trenker R, Call MJ*, Call ME*. Progress and prospects for structural studies of transmembrane interactions in single-spanning receptors. Curr Opin Struct Biol. 2016 Aug;39:115-123. PMID: 27423296
- Krshnan L, Park S, Im W, Call MJ*, Call ME*. A conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6649-E6658 PMID: 27791034
- Trenker R, Call ME*, Call MJ*. Crystal Structure of the Glycophorin A Transmembrane Dimer in Lipidic Cubic Phase. J Am Chem Soc. 2015 Dec 23;137(50):15676-9. PMID: 26642914
- Knoblich K, Park S, Lutfi M, van ’t Hag L, Conn CE, Seabrook SA, Newman J, Czabotar PE, Im W, Call ME* and Call MJ*. Transmembrane complexes of DAP12 crystallized in lipid membranes provide novel insights into control of oligomerization in immunoreceptor assembly. Cell Rep. 2015 May 26;11(8):1184-92 PMID: 25981043
- Berry R, Headey SJ, Call MJ, McCluskey J, Tregaskes CA, Kaufman J, Koh R, Scanlon MJ, Call ME & Rossjohn J. Structure of the chicken CD3epsilondelta/gamma heterodimer and its assembly with the alphabetaT cell receptor. J Biol Chem 2014. 289, 8240-8251 PMID:3961652