There is still much to learn about the normal biology of both T and B lymphocytes in the immune response.  We are particularly keen to understand how cells add signals together and adjust to changing levels and combinations of the many different cytokines and costimuli on offer during an immune challenge.  To reveal this ‘cellular calculus’ we measure cell behavior, at single cell and population level to learn the rules of addition and to predict the net outcomes. The effects of drugs and genetic manipulations on modular components of the cell are also being measured with the aim to develop a principle for predictive immunotherapy and in silico drug screening.

Members: The model team: Mark Dowling, Andrey Kan, John Markham, Ken Duffy (National University of Ireland) with the experimental team – Su Heinzel, Julia Marchingo, Jie Zhou, Bryan Lye.