Selected publications

1. Feltham R, Jamal K, Tenev T, Liccardi G, Jaco I, Domingues CM, Morris O, John SW, Annibaldi A, Widya M, Kearney CJ, Clancy D, Elliott PR, Glatter T, Qiao Q, Thompson AJ, Nesvizhskii A, Schmidt A, Komander D, Wu H, Martin S, Meier P. Mind bomb regulates cell death during TNF signaling by repressing RIPK1’s cytotoxic potential. Cell Rep. 2018 Apr 10;23(2):470-484. PMID: 29642005
2. Anderton H, Bandala-Sanchez E, Simpson DS, Rickard JA, Ng AP, Di Rago L, Hall C, Vince JE, Silke J, Liccardi G, Feltham R. RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development. Cell Death Differ. 2019 May;26(5):877-889. PMID: 30185824 
3. Lawlor KE*, Feltham R*, Yabal M*, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE. XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1b Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation. Cell Rep. 2017 Jul 18;20(3):668-682. PMID: 28723569 *co-first
4. Jaco I, Annibaldi A, Lalaoui N, Wilson R, Tenev T, Laurien L, Kim C, Jamal K, Wicky John S, Liccardi G, Chau D, Murphy JM, Brumatti G, Feltham R, Pasparakis M, Silke J, Meier P. MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. Mol Cell. 2017 Jun 1;66(5):698-710.e5. PMID: 28506461
5. Condon SM, Mitsuuchi Y, Deng Y, LaPorte MG, Rippin SR, Haimowitz T, Alexander MD, Kumar PT, Hendi MS, Lee YH, Benetatos CA, Yu G, Kapoor GS, Neiman E, Seipel ME, Burns JM, Graham MA, McKinlay MA, Li X, Wang J, Shi Y, Feltham R, Bettjeman B, Cumming MH, Vince JE, Khan N, Silke J, Day CL, Chunduru SK. Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumours and hematological malignancies. J Med Chem. 2014 May 8;57(9):3666-77 PMID: 24684347
6. Feltham R, Shirley S, Bettjeman B, Mace P, Vaux DL, Silke J, Day CL. Smac Mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING dimerisation. J Biol Chem. 2011 May 13;286(19):17015-28. PMID: 21393245
7. Feltham R, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J. TNF signaling, but not TWEAK triggered cIAP-TRAF2 degradation, requires cIAP1 RING dimerization and E2 binding. J Biol Chem. 2010 Jun 4;285(23):17525-36. PMID: 20356846
8. Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser E, Feltham R, Vince J, Warnken U, Wenger T, Koschny R, Komander D, Silke J, Walczak H. Recruitment of the linear ubiquitin chain assembly complex (LUBAC) stabilizes the TNF-R1 signaling complex and is required for TNF mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44. PMID: 20005846
9. Mace PD, Linke K, Feltham R, Schumacher FR, Smith CA, Vaux DL, Silke J, Day CL. Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment. J Biol Chem. 2008 Nov 14;283(46):31633-40. PMID: 18784070 
10. Vince JE, Wong WW, Khan N, Feltham R*, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, Brink R, Leverkus M, Tergaonkar V, Schneider P, Callus BA, Koentgen F, Vaux DL, Silke J. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):682-93. PMID: 18022363

Additional publications