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- A new regulator of stemness to create dendritic cell factories for immunotherapy
- Advanced methods for genomic rearrangement detection
- Control of cytokine signaling by SOCS1
- Defining the protein modifications associated with respiratory disease
- Delineating the pathways driving cancer development and therapy resistance
- Developing a new drug that targets plasmacytoid dendritic cells for the treatment of lupus
- Development and mechanism of action of novel antimalarials
- Development of a novel particle-based malaria vaccine
- Development of tau-specific therapeutic and diagnostic antibodies
- Discovering novel therapies for major human pathogens
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Epigenetic biomarkers of tuberculosis infection
- Essential role of glycobiology in malaria parasites
- Evolution of haematopoiesis in vertebrates
- Human lung protective immunity to tuberculosis
- Identifying novel treatment options for ovarian carcinosarcoma
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigating the role of mutant p53 in cancer
- Microbiome strain-level analysis using long read sequencing
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Modelling spatial and demographic heterogeneity of malaria transmission risk
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Structural basis of catenin-independent Wnt signalling
- Structure and biology of proteins essential for Toxoplasma parasite invasion
- T lymphocytes: how memories are made
- TICKER: A cell history recorder for longitudinal patient monitoring
- Targeting host pathways to develop new broad-spectrum antiviral drugs
- Targeting post-translational modifications to disrupting the function of secreted proteins
- Targeting the epigenome to rewire pro-allergic T cells
- Targeting the immune microenvironment to treat KRAS-mutant adenocarcinoma
- The E3 ubiquitin ligase Parkin and mitophagy in Parkinson’s disease
- The molecular controls on dendritic cell development
- Understanding malaria infection dynamics
- Understanding the genetics of neutrophil maturation
- Understanding the neuroimmune regulation of innate immunity
- Understanding the proteins that regulate programmed cell death at the molecular level
- Using cutting-edge single cell tools to understand the origins of cancer
- When healthy cells turn bad: how immune responses can transition to lymphoma
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Rhys Allan-Projects
Researcher:
Understanding the epigenetic control of immune cell fate and function
To study the contribution of epigenetic changes to immune processes, such as development and differentiation, we have established model systems that lack individual chromatin-modifying proteins from a number of epigenetic pathways. We combine these with gene expression analysis and DNA-binding sites of these modifiers to generate a more comprehensive understanding of how our immune system is controlled.
Identification of epigenetic targets for therapy of allergic disease
Atopic diseases such as allergic asthma and food allergy are on the rise in the industrialised world. Understanding the molecular wiring of the immune cells that drive autoimmune and allergic disease will allow in the identification of new treatments.
We use models of asthma and food allergy to explore the epigenetic requirements for T cell-driven allergic disease. We then target these epigenetic pathways with small molecule inhibitors to reverse allergic disease.
Exploring the establishment of chromatin architecture in lymphocytes
Although chromatin is traditionally viewed in a linear sense, recently it has been recognised that the higher order organisation of the chromatin and its position in the interphase nucleus is non-random and extremely relevant to biological function by regulating gene expression, DNA replication and repair, and recombination.
It is clearly important to understand how chromatin architecture is established during lymphocyte development. To do this we are using chromatin conformation capture technologies to understand how the chromatin is organised at the genome-wide level in lymphocytes.