Team

My lab collaborates closely with the Structural Biology division and other divisions in the Institute and elsewhere who study the protein interactions that regulate apoptosis in health and disease.

Sweta Iyer, Postdoctoral Fellow, BSc Biotech India MSc Genomics Madurai Kamaraj PhD Melbourne

Project: Directly regulation of BAK and BAX by novel antibodies

Key publication: Iyer S, Anwari K, Alsop AE, Yuen WS, Huang DC, Carroll J, Smith NA, Smith BJ, Dewson G, Kluck RM. Identification of an activation site in BAK and mitochondrial BAX triggered by antibodies. Nat Commun. 2016 May 24; 7:11734 PMID: 27217060 

Rachel Uren, Postdoctoral Fellow, BSc(Hons) PhD Melbourne

Project: Membrane topology of the BAK and BAX pores

Key publication: Uren RT, O'Hely M, Iyer S, Bartolo R, Brouwer JM, Alsop AE, Dewson G, Kluck RM. Disordered clusters of Bak dimers rupture mitochondria during apoptosis. Elife. 2017 Feb 6;6. PMID: 28182867

Hema Preethi Subas-Satish, PhD Student, BSc Tech Chennai, MSc Biotech Qld

Project: Engineering antibodies to trigger BAK-mediated apoptosis in cancer

Key publication: Iyer S, Anwari K, Alsop AE, Yuen WS, Huang DC, Carroll J, Smith NA, Smith BJ, Dewson G, Kluck RM. Identification of an activation site in BAK and mitochondrial BAX triggered by antibodies. Nat Commun. 2016. PMID: 27217060

Melissa Shi, Research Assistant, BSc(Hons) Melbourne

Project: Determining how MCL-1 contributes to resistance during anti-cancer treatment

Key publication: Hockings C, Alsop AE, Fennell SC, Lee EF, Fairlie WD, Dewson G and Kluck RM. Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins. Cell Death Differ. 2018. PMID: 29459767