In the human host, complement regulators modulate the complement cascade to protect self-tissue from indiscriminate complement attack. Pathogens, on the other hand actively recruit host regulators with the foremost intention of inhibiting the complement cascade to prevent pathogen destruction. The acquisition of host complement regulators is the most widely used strategy for complement evasion among viruses, bacteria, fungi and parasites. This project will involve identifying which complement regulators are recruited by malaria parasites and how this prevents killing. It will also investigate the role of parasite surface proteins in recruitment of human complement regulators. This project will provide the first identification of complement evasion strategies employed by the malaria parasite.