Professor Craig M. Williams - University of Queensland

Professor Craig M. Williams - University of Queensland

Location: 
Seminar Room 1
Start Time: 
Fri, 23/08/2019 - 2:00pm
End Time: 
Fri, 23/08/2019 - 3:00pm

​Aspects of Natural Products, Hydrocarbon Bioisosteres, and Synthetic Methodology

​Special seminar hosted by Professor Guillaume Lessene

Human health and agriculture have benefitted greatly from both natural products and de novo synthetics in terms of medicines in the clinic and the control of food security. Behind the scenes natural product isolation has provided exquisite molecules, with human kind developing elegantly simple compounds, both being very effective in controlling numerous biological pathways. Organic synthesis continues to be a crucial part of these endeavours through total and target orientated synthesis, underpinning biological evaluation (SAR), candidate development and process chemistry. Omnipresent in this field are opportunities to provide student training, discover technical innovations and stimulate academic learning, not to mention opening tangential opportunities in discovering new synthetic methodology, physical organic and medicinal/agri chemistry. The lecture will canvas some of these concepts using select examples above and more.

Associate Professor Craig Williams is the Group Leader of the Natural Products Total Synthesis group in the School of Chemistry and Molecular Biosciences, Faculty of Science at the University of Queensland. He is an organic chemist with a research focus and expertise orientated around constructing and attempting to construct very complex biologically active natural products and drug like molecules. These projects have instilled highlevel chemical competency within his group, which allow the team to tackle both simple and complex problems in associated areas such as medicinal and physical chemistry. Targets and areas of expertise cover diterpenes, diterpene alkaloids, alkaloids/opioids, tetranortriterpenes, polyketides, polycyclic hydrocarbons, saturated and unsaturated nitrogen, oxygen and sulfur containing heterocycles. Craig also undertakes isolation and elucidation of natural products, although much of this work has not been published due to commercial in confidence research contracts with local BioTechnology companies.