Professor Stephen Nutt - Immunology division

Professor Stephen Nutt - Immunology division

Location: 
Davis Auditorium
Start Time: 
Wed, 28/04/2021 - 1:00pm
End Time: 
Wed, 28/04/2021 - 2:00pm

WEHI Wednesday Seminar hosted by Professor Phil Hodgkin

 

Professor Stephen Nutt

Laboratory Head, Immunology division -  Infection, Inflammation & Immunity Theme

 

Gene regulation in the immune system

 

Online access via Slido and enter code #WEHIWEDNESDAY

Including Q&A session

 

A fundamental problem for any multicellular organism is how to generate multiple genetically identical, yet functionally distinct, cell types from a common progenitor. This question is particularly pertinent and clinically relevant within the immune system, as a large number of distinct cellular lineages and subsets need to be generated throughout the life of the individual. Defects in cellular differentiation underpin many immunological diseases, including blood cell cancers, immune deficiency and autoimmunity.

 

The differentiation and function of the various immune cell types is controlled by the interplay of cell intrinsic and extrinsic factors. The predominant intrinsic components controlling immune cell fate are transcription factors; DNA binding proteins that are able to both promote and repress gene expression depending on the cellular context. Transcription factors ensure that appropriate cell type specific genes are activated and that the potential responsiveness to signals for other lineages is suppressed, thereby promoting a particular cell fate or differentiation stage.

 

Focusing on examples from the immune system, including dendritic cells and lymphocytes, this seminar will outline our approaches to understand how key transcription factors function to program the differentiation of the diverse sets of cells that collectively provide protective immunity.