Characterising new regulators in inflammatory signalling pathways

Characterising new regulators in inflammatory signalling pathways

Project details

Ubiquitination is an essential post-translational modification, which regulates various cellular processes. As deregulation of ubiquitin signalling causes several diseases, including autoinflammatory diseases and cancers, it is important to understand how ubiquitin signalling is tightly regulated. We are interested in the regulatory mechanism of linear ubiquitin chains in cytokine and innate immune signalling pathways.

Our previous work has revealed that the deubiquitinase OTULIN, which disassembles linear ubiquitin chains, is essential for preventing systemic inflammation (Damgaard, Cell 2016 166 (5): 1215), but the molecular mechanisms underlying the linear ubiquitin chain regulation are not fully understood.

In your project, you will characterise new regulators of this pathway using a variety of techniques, including biochemistry, molecular biology and in vivo disease models.

About our research group

The Komander laboratory is a core part of Ubiquitin Signalling division that focuses on understanding ubiquitin and ubiquitin-like modifications. We are interested in neurodegenerative diseases and autoinflammatory diseases, particularly from the aspect of protein ubiquitination. Our laboratory combines diverse techniques, including structural biology, biochemistry, biophysics and mass-spectrometry, cell biology and preclinical model to decipher the ubiquitin code. By continuing to decipher the ubiquitin code, we hope to discover and develop new drugs to treat a variety of human diseases.


Dr Yuri Shibata
Ubiquitin Signalling division

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