Epigenetic regulation of systemic iron homeostasis

Epigenetic regulation of systemic iron homeostasis

Project details 

Our group works on basic, translational, clinical and public health aspects of anaemia control.

Daily (circadian) variations in systemic iron are known but the epigenetic regulation is unknown. Understanding these variations could lead to better treatment of iron-deficient patients.

We recently provided the first evidence of epigenetic regulation of the master iron regulatory hormone, hepcidin (Pasricha et al Nat Commun 2016 Sep 1;8(1):403.) This project will use a combination of cutting edge epigenetic (for example chromosome conformation capture, ATAC-Seq, ChIP), and molecular (for example qPCR, western blot) techniques to characterise the circadian regulation of iron.

Students will learn a series of high throughput sequencing methods, as well as become familiar with aspects of iron biology.

About our research group 

We combine basic experimental science with research in global health.

In the laboratory, we study how the master controller of systemic iron homoestasis, hepcidin, is regulated and how it affects disease severity. We are using novel epigenetic approaches to characterise new pathways which may regulate hepcidin gene expression.

In the field, we are undertaking large randomised controlled trials of iron interventions in rural Bangladesh (infants) and Malawi (pregnant women). These trials will provide much needed evidence to inform global health anaemia control policies.

Finally, we assist and advise international and national organisations with research and policy development.

Researchers:

Dr Sant-Rayn Pasricha

Dr Sant-Rayn Pasricha
Dr
Sant-Rayn
Pasricha
Joint Division Head
Dr Cavan Bennett
Dr
Cavan
Bennett
Population Health and Immunity division

Project Type: