Novel therapies for ovarian carcinoma and other rare cancers

Novel therapies for ovarian carcinoma and other rare cancers

Project details

Ovarian and endometrioid carcinosarcoma (OCS and ECS) are lethal gynaecological cancers. Few evidence-based treatment options are available because the cancers are rare, limiting the collection of data. Standard treatments comprise surgery with radiotherapy and platinum-based chemotherapy. Most patients relapse within one year of treatment and have a median overall survival of less than two years.

This project will involve the analysis of patient samples from these and other rare gynaecological cancers using a variety of techniques including genomics, 3D organoid culture, patient-derived xenografts, live cell imaging, immune profiling, drug library screening, and CRISPR screening. The aim is to identify pathways that mediate response to conventional chemotherapeutics and that show potential for targeting with novel agents, to inform clinical trial design in these under-studied cancers.

About our research group

The Scott laboratory has a strong emphasis on research that has potential for clinical translation. Our relatively large laboratory of 15 is made up of a combination of clinician scientists, post-doctoral fellows, students and research assistants. We have a strong collaborative ethic and while the lab is working on two main projects – rare cancer and ovarian cancer – technical expertise and resources are shared between both groups. There is a variety of expertise within the group including bioinformatics, genomics and cell biology.  

The Papenfuss laboratory applies mathematics, statistics and computing to make sense of genomics data from cancer. The laboratory develops novel bioinformatics methods to analyse data and has a particular focus on developing strategies for diagnosing and treating patients with rare cancers.


Professor Clare Scott

Professor Clare Scott
Joint Division Head

Professor Tony Papenfuss

Tony Papenfuss
Laboratory Head; Leader, Computational Biology Theme
Dr Holly Barker in the lab
ACRF Cancer Biology and Stem Cells division

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